Monday, June 28, 2010

Monday June 28, 2010 - Blood Tests

This morning Barry had blood work done. He usually gets blood tests at least once per week. Here are the results of the blood tests this morning. The doctors figure that Barry can go about two more days before he needs a transfusion of platelets.

WBC - 4.7
Hemoglobin - 8.2
Platelet - 24
Neutrophils, Abs - 2.10

Wednesday, June 23, 2010

June 23, 2010 - Platelet Transfusion Today

On Wednesday June 23, 2010, Barry got a platelet transfusion. His platelet levels were down to 4 (or 4 x 10^9 per liter). Just to give you an idea, the normal platelet range is 150-400 x 10^9 per liter. Also, the results of Barry's bone marrow biopsy (third one after transplant) on June 9th showed that his MRD was at 29.3%. The MRD decreased from 29.7% (second biopsy after transplant) to 29.3% so this is okay. As long as Barry's leukemia doesn't grow, we can keep him off of chemotherapy so that he can get stronger. Then at the six month mark after transplant (October 2010), we can do another bone marrow transplant.

Saturday, June 12, 2010

June 12, 2010 - Returning Home

On Saturday June 12th, 2010 at noon, we brought Barry to home sweet home. We had been staying at the Ronald McDonald House since May 12th, 2010. Although the Ronald McDonald House is a convenient place to stay because it is so close to the hospital, there is no place like home.

Wednesday, June 9, 2010

June 9, 2010 - 3rd Bone Marrow Biopsy and Aspirate Since Transplant

Today, Wednesday June 9th, 2010, they are going to do a bone marrow biopsy and aspirate on Barry. This is his third bone marrow biopsy since transplant. They are going to check the MRD to see how many percent blasts Barry has in his bone marrow. If the blast percentage is decreasing then this would be good. We would like to see the blast percentage be less than the 27% of the second bone marrow biopsy. This would further confirm that the GvL is taking effect in his body. I will post the results of his bone marrow biopsy as soon as I know. The results should probably come back on Friday.

Thursday, June 3, 2010

Update on Barry - June 3, 2010

We are going to do another bone marrow biopsy and aspiration on Barry on Wednesday June 9, 2010. They are going to check his VNTR and MRD to see the trend. Previously, Barry had two bone marrow biopsies done on May 11th and May 21st. The May 11th bone marrow biopsy showed 41% blasts (not good) and a CD34+ engraftment of 9% (not good). The May 21st bone marrow biopsy showed 27% blasts (better) and a CD34+ engraftment of 93% (good). So I asked Dr. Ga***n and he said that they really don't know and can't explain exactly what is going on with Barry; that is a fair answer and I can accept that. The blast percentage going down from 41% to 27% is the graft vs leukemia effect; if this trend continues then this is good. It is also unclear how his engraftment of the CD34+ cells jumped from 9% to 93%. So we have two data points already and the bone marrow biopsy next week will give us a third data point.

Barry's cytogenetics test results also show a 7q- chromosomal abnormality. This means that he may already have or might be developing myelodysplastic syndrome. The cure for MDS is also a bone marrow transplant. So to sum it up, we will still need to do a second bone marrow transplant for Barry. Overall, he looks pretty healthy and if you saw him, you would not even know that he has cancer.