We are going to do another bone marrow biopsy and aspiration on Barry on Wednesday June 9, 2010. They are going to check his VNTR and MRD to see the trend. Previously, Barry had two bone marrow biopsies done on May 11th and May 21st. The May 11th bone marrow biopsy showed 41% blasts (not good) and a CD34+ engraftment of 9% (not good). The May 21st bone marrow biopsy showed 27% blasts (better) and a CD34+ engraftment of 93% (good). So I asked Dr. Ga***n and he said that they really don't know and can't explain exactly what is going on with Barry; that is a fair answer and I can accept that. The blast percentage going down from 41% to 27% is the graft vs leukemia effect; if this trend continues then this is good. It is also unclear how his engraftment of the CD34+ cells jumped from 9% to 93%. So we have two data points already and the bone marrow biopsy next week will give us a third data point.
Barry's cytogenetics test results also show a 7q- chromosomal abnormality. This means that he may already have or might be developing myelodysplastic syndrome. The cure for MDS is also a bone marrow transplant. So to sum it up, we will still need to do a second bone marrow transplant for Barry. Overall, he looks pretty healthy and if you saw him, you would not even know that he has cancer.